SUBPART - Subpart F—Flavoring Agents and Related Substances

Collapse to view only § 172.530 - Disodium guanylate.

§ 172.510 - Natural flavoring substances and natural substances used in conjunction with flavors.
§ 172.515 - Synthetic flavoring substances and adjuvants.
§ 172.520 - Cocoa with dioctyl sodium sulfosuccinate for manufacturing.
§ 172.530 - Disodium guanylate.
§ 172.535 - Disodium inosinate.
§ 172.540 - DL-Alanine.
§ 172.560 - Modified hop extract.
§ 172.575 - Quinine.
§ 172.580 - Safrole-free extract of sassafras.
§ 172.585 - Sugar beet extract flavor base.
§ 172.590 - Yeast-malt sprout extract.

§ 172.510 - Natural flavoring substances and natural substances used in conjunction with flavors.

Natural flavoring substances and natural adjuvants may be safely used in food in accordance with the following conditions.

(a) They are used in the minimum quantity required to produce their intended physical or technical effect and in accordance with all the principles of good manufacturing practice.

(b) In the appropriate forms (plant parts, fluid and solid extracts, concentrates, absolutes, oils, gums, balsams, resins, oleoresins, waxes, and distillates) they consist of one or more of the following, used alone or in combination with flavoring substances and adjuvants generally recognized as safe in food, previously sanctioned for such use, or regulated in any section of this part.

Common name	Scientific name	Limitations	Aloe	Aloe perryi Baker, A. barbadensis Mill., A. ferox Mill., and hybrids of this sp. with A. africana Mill. and A. spicata Baker		Althea root and flowers	Althea officinalis L		Amyris (West Indian sandalwood)	Amyris balsamifera L		Angola weed	Roccella fuciformis Ach	In alcoholic beverages only	Arnica flowers	Arnica montana L., A. fulgens Pursh, A. sororia Greene, or A. cordifolia Hooker	Do.	Artemisia (wormwood)	Artemisia spp	Finished food thujone free 1	Artichoke leaves	Cynara scolymus L	In alcoholic beverages only	Benzoin resin	Styrax benzoin Dryander, S. paralleloneurus Perkins, S. tonkinensis (Pierre) Craib ex Hartwich, or other spp. of the Section Anthostyrax of the genus Styrax		Blackberry bark	Rubus, Section Eubatus		Boldus (boldo) leaves	Peumus boldus Mol	Do.	Boronia flowers	Boronia megastigma Nees		Bryonia root	Bryonia alba L., or B. diocia Jacq	Do.	Buchu leaves	Barosma betulina Bartl. et Wendl., B. crenulata (L.) Hook. or B. serratifolia Willd		Buckbean leaves	Menyanthes trifoliata L	Do.	Cajeput	Melaleuca leucadendron L. and other Melaleuca spp		Calumba root	Jateorhiza palmata (Lam.) Miers	Do.	Camphor tree	Cinnamomum camphora (L.) Nees et Eberm	Safrole free	Cascara sagrada	Rhamnus purshiana DC		Cassie flowers	Acacia farnesiana (L.) Willd		Castor oil	Ricinus communis L		Catechu, black	Acacia catechu Willd		Cedar, white (aborvitae), leaves and twigs	Thuja occidentalis L	Finished food thujone free 1	Centuary	Centaurium umbellatum Gilib	In alcoholic beverages only	Cherry pits	Prunus avium L. or P. cerasus L	Not to exceed 25 p.p.m. prussic acid	Cherry-laurel leaves	Prunus laurocerasus L	Do.	Chestnut leaves	Castanea dentata (Marsh.) Borkh		Chirata	Swertia chirata Buch.-Ham	In alcoholic beverages only	Cinchona, red, bark	Cinchona succirubra Pav. or its hybrids	In beverages only; not more than 83 p.p.m. total cinchona alkaloids in finished beverage	Cinchona, yellow, bark	Cinchona ledgeriana Moens, C. calisaya Wedd., or hybrids of these with other spp. of Cinchona.	Do.	Copaiba	South American spp. of Copaifera L		Cork, oak	Quercus suber L., or Q. occidentalis F. Gay	In alcoholic beverages only	Costmary	Chrysanthemum balsamita L	Do.	Costus root	Saussurea lappa Clarke		Cubeb	Piper cubeba L. f		Currant, black, buds and leaves	Ribes nigrum L		Damiana leaves	Turnera diffusa Willd		Davana	Artemisia pallens Wall		Dill, Indian	Anethum sowa Roxb. (Peucedanum graveolens Benth et Hook., Anethum graveolens L.)		Dittany (fraxinella) roots	Dictamnus albus L	Do.	Dittany of Crete	Origanum dictamnus L		Dragon's blood (dracorubin)	Daemonorops spp		Elder tree leaves	Sambucus nigra L	In alcoholic beverages only; not to exceed 25 p.p.m. prussic acid in the flavor	Elecampane rhizome and roots	Inula helenium L	In alcoholic beverages only	Elemi	Canarium commune L. or C. luzonicum Miq		Erigeron	Erigeron canadensis L		Eucalyptus globulus leaves	Eucalyptus globulus Labill		Fir (“pine”) needles and twigs	Abies sibirica Ledeb., A. alba Mill., A. sachalinesis Masters or A. mayriana Miyabe et Kudo		Fir, balsam, needles and twigs	Abies balsamea (L.) Mill		Galanga, greater	Alpinia galanga Willd	Do.	Galbanum	Ferula galbaniflua Boiss. et Buhse and other Ferula spp		Gambir (catechu, pale)	Uncaria gambir Roxb		Genet flowers	Spartium junceum L		Gentian rhizome and roots	Gentiana lutea L		Gentian, stemless	Gentiana acaulis L	Do.	Germander, chamaedrys	Teucrium chamaedrys L	Do.	Germander, golden	Teucrium polium L	Do.	Guaiac	Guaiacum officinale L., G. santum L., Bulnesia sarmienti Lor		Guarana	Paullinia cupana HBK		Haw, black, bark	Viburnum prunifolium L		Hemlock needles and twigs	Tsuga canadensis (L.) Carr. or T. heterophylla (Raf.) Sarg		Hyacinth flowers	Hyacinthus orientalis L		Iceland moss	Cetraria islandica Ach	Do.	Imperatoria	Peucedanum ostruthium (L.). Koch (Imperatoria ostruthium L.)		Iva	Achillea moschata Jacq	Do.	Labdanum	Cistus spp		Lemon-verbena	Lippia citriodora HBK	Do.	Linaloe wood	Bursera delpechiana Poiss. and other Bursera spp		Linden leaves	Tillia spp	Do.	Lovage	Levisticum officinale Koch		Lungmoss (lungwort)	Sticta pulmonacea Ach		Maidenhair fern	Adiantum capillus-veneris L	Do.	Maple, mountain	Acer spicatum Lam		Mimosa (black wattle) flowers	Acacia decurrens Willd. var. dealbata		Mullein flowers	Verbascum phlomoides L. or V. thapsiforme Schrad	Do.	Myrrh	Commiphora molmol Engl., C. abyssinica (Berg) Engl., or other Commiphora spp		Myrtle leaves	Myrtus communis L	Do.	Oak, English, wood	Quercus robur L	Do.	Oak, white, chips	Quercus alba L		Oak moss	Evernia prunastri (L.) Ach., E. furfuracea (L.) Mann, and other lichens	Finished food thujone free 1	Olibanum	Boswellia carteri Birdw. and other Boswellia spp		Opopanax (bisabolmyrrh)	Opopanax chironium Koch (true opopanax) of Commiphora erythraea Engl. var. Llabrescens		Orris root	Iris germanica L. (including its variety florentina Dykes) and I. pallida Lam		Pansy	Viola tricolor L	In alcoholic beverages only	Passion flower	Passiflora incarnata L		Patchouly	Pogostemon cablin Benth. and P. heyneanus Benth		Peach leaves	Prunus persica (L.) Batsch	In alcoholic beverages only; not to exceed 25 p.p.m. prussic acid in the flavor	Pennyroyal, American	Hedeoma pulegioides (L.) Pers		Pennyroyal, European	Mentha pulegium L		Pine, dwarf, needles and twigs	Pinus mugo Turra var. pumilio (Haenke) Zenari		Pine, Scotch, needles and twigs	Pinus sylvestris L		Pine, white, bark	Pinus strobus L	In alcoholic beverages only	Pine, white oil	Pinus palustris Mill., and other Pinus spp		Poplar buds	Populus balsamifera L. (P. tacamahacca Mill.), P. candicans Ait., or P. nigra L	Do.	Quassia	Picrasma excelsa (Sw.) Planch, or Quassia amara L		Quebracho bark	Aspidosperma quebracho-blanco Schlecht, or (Quebrachia lorentzii (Griseb))	Schinopsis lorentzii (Griseb.) Engl.	Quillaia (soapbark)	Quillaja saponaria Mol		Red saunders (red sandalwood)	Pterocarpus san alinus L	In alcoholic beverages only	Rhatany root	Krameria triandra Ruiz et Pav. or K. argentea Mart		Rhubarb, garden root	Rheum rhaponticum L	Do.	Rhubarb root	Rheum officinale Baill., R. palmatum L., or other spp. (excepting R. rhaponticum L.) or hybrids of Rheum grown in China		Roselle	Hibiscus sabdariffa L	Do.	Rosin (colophony)	Pinus palustris Mill., and other Pinus spp	Do.	St. Johnswort leaves, flowers, and caulis	Hypericum perforatum L	Hypericin-free alcohol distillate form only; in alcoholic beverages only	Sandalwood, white (yellow, or East Indian)	Santalum album L		Sandarac	Tetraclinis articulata (Vahl.), Mast	In alcoholic beverages only	Sarsaparilla	Smilax aristolochiaefolia Mill., (Mexican sarsaparilla), S. regelii Killip et Morton (Honduras sarsaparilla), S. febrifuga Kunth (Ecuadorean sarsaparilla), or undetermined Smilax spp. (Ecuadorean or Central American sarsaparilla)		Sassafras leaves	Sassafras albidum (Nutt.) Nees	Safrole free	Senna, Alexandria	Cassia acutifolia Delile		Serpentaria (Virginia snakeroot)	Aristolochia serpentaria L	In alcoholic beverages only	Simaruba bark	Simaruba amara Aubl	Do.	Snakeroot, Canadian (wild ginger)	Asarum canadense L		Spruce needles and twigs	Picea glauca (Moench) Voss or P. mariana (Mill.) BSP		Storax (styrax)	Liquidambar orientalis Mill. or L. styraciflua L		Tagetes (marigold)	Tagetes patula L., T. erecta L., or T. minuta L. (T. glandulifera Schrank)	As oil only	Tansy	Tanacetum vulgare L	In alcoholic beverages only; finished alcoholic beverage thujone free 1	Thistle, blessed (holy thistle)	Onicus benedictus L	In alcoholic beverages only	Thymus capitatus (Spanish “origanum”)	Thymus capitatus Hoffmg. et Link		Tolu	Myroxylon balsamum (L.) Harms		Turpentine	Pinus palustris Mill. and other Pinus spp. which yield terpene oils exclusively		Valerian rhizome and roots	Valeriana officinalis L		Veronica	Veronica officinalis L	Do.	Vervain, European	Verbena officinalis L	Do.	Vetiver	Vetiveria zizanioides Stapf	Do.	Violet, Swiss	Viola calcarata L		Walnut husks (hulls), leaves, and green nuts	Juglans nigra L. or J. regia L		Woodruff, sweet	Asperula odorata L	In alcoholic beverages only	Yarrow	Achillea millefolium L	In beverages only; finished beverage thujone free 1	Yerba santa	Eriodictyon californicum (Hook, et Arn.) Torr		Yucca, Joshua-tree	Yucca brevifolia Engelm		Yucca, Mohave	Yucca schidigera Roezl ex Ortgies (Y. mohavensis Sarg.)

1 As determined by using the method (or, in other than alcoholic beverages, a suitable adaptation thereof) in section 9.129 of the “Official Methods of Analysis of the Association of Official Analytical Chemists,” 13th Ed. (1980), which is incorporated by reference. Copies may be obtained from the AOAC INTERNATIONAL, 481 North Frederick Ave., suite 500, Gaithersburg, MD 20877, or may be examined at the National Archives and Records Administration (NARA). For information on the availability of this material at NARA, call 202-741-6030, or go to: http://www.archives.gov/federal_register/code_of_federal_regulations/ibr_locations.html.

[42 FR 14491, Mar. 15, 1977, as amended at 43 FR 14644, Apr. 7, 1978; 49 FR 10104, Mar. 19, 1984; 54 FR 24897, June 12, 1989; 69 FR 24511, May 4, 2004; 72 FR 10357, Mar. 8, 2007]

§ 172.515 - Synthetic flavoring substances and adjuvants.

Synthetic flavoring substances and adjuvants may be safely used in food in accordance with the following conditions.

(a) They are used in the minimum quantity required to produce their intended effect, and otherwise in accordance with all the principles of good manufacturing practice.

(b) They consist of one or more of the following, used alone or in combination with flavoring substances and adjuvants generally recognized as safe in food, prior-sanctioned for such use, or regulated by an appropriate section in this part.

Acetal; acetaldehyde diethyl acetal. Acetaldehyde phenethyl propyl acetal. Acetanisole; 4′-methoxyacetophenone. Acetophenone; methyl phenyl ketone. Allyl anthranilate. Allyl butyrate. Allyl cinnamate. Allyl cyclohexaneacetate. Allyl cyclohexanebutyrate. Allyl cyclohexanehexanoate. Allyl cyclohexaneproprionate. Allyl cyclohexanevalerate. Allyl disulfide. Allyl 2-ethylbutyrate. Allyl hexanoate; allyl caproate. Allyl α-ionone; 1-(2,6,6-trimethyl-2-cyclo-hexene-1-yl)-1,6-heptadiene-3-one. Allyl isothiocyanate; mustard oil. Allyl isovalerate. Allyl mercaptan; 2-propene-1-thiol. Allyl nonanoate. Allyl octanoate. Allyl phenoxyacetate. Allyl phenylacetate. Allyl propionate. Allyl sorbate; allyl 2,4-hexadienoate. Allyl sulfide. Allyl tiglate; allyl trans-2-methyl-2-butenoate. Allyl 10-undecenoate. Ammonium isovalerate. Ammonium sulfide. Amyl alcohol; pentyl alcohol. Amyl butyrate. α-Amylcinnamaldehyde. α-Amylcinnamaldehyde dimethyl acetal. α-Amylcinnamyl acetate. α-Amylcinnamyl alcohol. α-Amylcinnamyl formate. α-Amylcinnamyl isovalerate. Amyl formate. Amyl heptanoate. Amyl hexanoate. Amyl octanoate. Anisole; methoxybenzene. Anisyl acetate. Anisyl alcohol; p-methoxybenzyl alcohol. Anisyl butyrate Anisyl formate. Anisyl phenylacetate. Anisyl propionate. Beechwood creosote. Benzaldehyde dimethyl acetal. Benzaldehyde glyceryl acetal; 2-phenyl-m-dioxan-5-ol. Benzaldehyde propylene glycol acetal; 4-methyl-2-phenyl-m-dioxolane. Benzenethiol; thiophenol. Benzoin; 2-hydroxy-2-phenylacetophenone. Benzyl acetate. Benzyl acetoacetate. Benzyl alcohol. Benzyl benzoate. Benzyl butyl ether. Benzyl butyrate. Benzyl cinnamate. Benzyl 2,3-dimethylcrotonate; benzyl methyl tiglate. Benzyl disulfide; dibenzyl disulfide. Benzyl ethyl ether. Benzyl formate. 3-Benzyl-4-heptanone; benzyl dipropyl ketone. Benzyl isobutyrate. Benzyl isovalerate. Benzyl mercaptan; α-toluenethiol. Benzyl methoxyethyl acetal; acetaldehyde benzyl β-methoxyethyl acetal. Benzyl phenylacetate. Benzyl propionate. Benzyl salicylate. Birch tar oil. Borneol; d-camphanol. Bornyl acetate. Bornyl formate. Bornyl isovalerate. Bornyl valerate. β-Bourbonene; 1,2,3,3a,3bβ,4,5,6,6aβ,6bα-deca-hydro-lα-isopropyl-3aa-methyl-6-methylene-cyclobuta [1,2:3,4] dicyclopentene. 2-Butanol. 2-Butanone; methyl ethyl ketone. Butter acids. Butter esters. Butyl acetate. Butyl acetoacetate. Butyl alcohol; 1-butanol. Butyl anthranilate. Butyl butyrate. Butyl butyryllactate; lactic acid, butyl ester, butyrate. α-Butylcinnamaldehyde. Butyl cinnamate. Butyl 2-decenoate. Butyl ethyl malonate. Butyl formate. Butyl heptanoate. Butyl hexanoate. Butyl p-hydroxybenzoate. Butyl isobutyrate. Butyl isovalerate. Butyl lactate. Butyl laurate. Butyl levulinate. Butyl phenylacetate. Butyl propionate. Butyl stearate. Butyl sulfide. Butyl 10-undecenoate. Butyl valerate. Butyraldehyde. Cadinene. Camphene; 2,2-dimethyl-3-methylenenorbornane. d-Camphor. Carvacrol; 2-p-cymenol. Carvacryl ethyl ether; 2-ethoxy-p-cymene. Carveol; p-mentha-6,8-dien-2-ol. 4-Carvomenthenol; 1-p-menthen-4-ol; 4-terpinenol. cis Carvone oxide; 1,6-epoxy-p-menth-8-en-2-one. Carvyl acetate. Carvyl propionate. β-Caryophyllene. Caryophyllene alcohol. Caryophyllene alcohol acetate. β-Caryophyllene oxide; 4-12,12-trimethyl-9-methylene-5-oxatricylo [8.2.0.0 4 6] dodecane. Cedarwood oil alcohols. Cedarwood oil terpenes. 1,4-Cineole. Cinnamaldehyde ethylene glycol acetal. Cinnamic acid. Cinnamyl acetate. Cinnamyl alcohol; 3-phenyl-2-propen-1-ol. Cinnamyl benzoate. Cinnamyl butyrate. Cinnamyl cinnamate. Cinnamyl formate. Cinnamyl isobutyrate. Cinnamyl isovalerate. Cinnamyl phenylacetate. Cinnamyl propionate. Citral diethyl acetal; 3,7-dimethyl-2,6-octadienal diethyl acetal. Citral dimethyl acetal; 3,7-dimethyl-2,6-octadienal dimethyl acetal. Citral propylene glycol acetal. Citronellal; 3,7-dimethyl-6-octenal; rhodinal. Citronellol; 3,7-dimethyl-6-octen-1-ol; d-citronellol. Citronelloxyacetaldehyde. Citronellyl acetate. Citronellyl butyrate. Citronellyl formate. Citronellyl isobutyrate. Citronellyl phenylacetate. Citronellyl propionate. Citronellyl valerate. p-Cresol. Cuminaldehyde; cuminal; p-isopropyl benzaldehyde. Cyclohexaneacetic acid. Cyclohexaneethyl acetate. Cyclohexyl acetate. Cyclohexyl anthranilate. Cyclohexyl butyrate. Cyclohexyl cinnamate. Cyclohexyl formate. Cyclohexyl isovalerate. Cyclohexyl propionate. p-Cymene. γ-Decalactone; 4-hydroxy-decanoic acid, γ-lactone. γ-Decalactone; 5-hydroxy-decanoic acid, δ-lactone. Decanal dimethyl acetal. 1-Decanol; decylic alcohol. 2-Decenal. 3-Decen-2-one; heptylidene acetone. Decyl actate. Decyl butyrate. Decyl propionate. Dibenzyl ether. 4,4-Dibutyl-γ-butyrolactone; 4,4-dibutyl-4-hydroxy-butyric acid, γ-lactone. Dibutyl sebacate. Diethyl malate. Diethyl malonate; ethyl malonate. Diethyl sebacate. Diethyl succinate. Diethyl tartrate. 2,5-Diethyltetrahydrofuran. Dihydrocarveol; 8-p-menthen-2-ol; 6-methyl-3-isopropenylcyclohexanol. Dihydrocarvone. Dihydrocarvyl acetate. m-Dimethoxybenzene. p-Dimethoxybenzene; dimethyl hydroquinone. 2,4-Dimethylacetophenone. α,α-Dimethylbenzyl isobutyrate; phenyldimethylcarbinyl isobutyrate. 2,6-Dimethyl-5-heptenal. 2,6-Dimethyl octanal; isodecylaldehyde. 3,7-Dimethyl-1-octanol; tetrahydrogeraniol. α,α-Dimethylphenethyl acetate; benzylpropyl acetate; benzyldimethylcarbinyl acetate. α,α-Dimethylphenethyl alcohol; dimethylbenzyl carbinol. α,α-Dimethylphenethyl butyrate; benzyldimethylcarbinyl butyrate. α,α-Dimethylphenethyl formate; benzyldimethylcarbinyl formate. Dimethyl succinate. 1,3-Diphenyl-2-propanone; dibenzyl ketone. delta-Dodecalactone; 5-hydroxydodecanoic acid, deltalactone. γ-Dodecalactone; 4-hydroxydodecanoic acid γ-lactone. 2-Dodecenal. Estragole. ρ-Ethoxybenzaldehyde. Ethyl acetoacetate. Ethyl 2-acetyl-3-phenylpropionate; ethylbenzyl acetoacetate. Ethyl aconitate, mixed esters. Ethyl ρ-anisate. Ethyl anthranilate. Ethyl benzoate. Ethyl benzoylacetate. α-Ethylbenzyl butyrate; α-phenylpropyl butyrate. Ethyl brassylate; tridecanedioic acid cyclic ethylene glycol diester; cyclo 1,13-ethyl-enedioxytridecan-1,13-dione. 2-Ethylbutyl acetate. 2-Ethylbutyraldehyde. 2-Ethylbutyric acid. Ethyl cinnamate. Ethyl crotonate; trans-2-butenoic acid ethylester. Ethyl cyclohexanepropionate. Ethyl decanoate. 2-Ethylfuran. Ethyl 2-furanpropionate. 4-Ethylguaiacol; 4-ethyl-2-methoxyphenol. Ethyl heptanoate. 2-Ethyl-2-heptenal; 2-ethyl-3-butylacrolein. Ethyl hexanoate. Ethyl isobutyrate. Ethyl isovalerate. Ethyl lactate. Ethyl laurate. Ethyl levulinate. Ethyl maltol; 2-ethyl-3-hydroxy-4H-pyran-4-one. Ethyl 2-methylbutyrate. Ethyl myristate. Ethyl nitrite. Ethyl nonanoate. Ethyl 2-nonynoate; ethyl octyne carbonate. Ethyl octanoate. Ethyl oleate. Ethyl phenylacetate. Ethyl 4-phenylbutyrate. Ethyl 3-phenylglycidate. Ethyl 3-phenylpropionate; ethyl hydrocinnamate. Ethyl propionate. Ethyl pyruvate. Ethyl salicylate. Ethyl sorbate; ethyl 2,4-hexadienoate. Ethyl tiglate; ethyl trans-2-methyl-2-butenoate. Ethyl undecanoate. Ethyl 10-undecenoate. Ethyl valerate. Eucalyptol; 1,8-epoxy-p-menthane; cineole. Eugenyl acetate. Eugenyl benzoate. Eugenyl formate. Farnesol; 3,7,11-trimethyl-2,6,10-dodecatrien-1-ol. d-Fenchone; d-1,3,3-trimethyl-2-norbornanone. Fenchyl alcohol; 1,3,3-trimethyl-2-norbornanol. Formic acid (2-Furyl)-2-propanone; furyl acetone. 1-Furyl-2-propanone; furyl acetone. Fusel oil, refined (mixed amyl alcohols). Geranyl acetoacetate; trans-3,7-dimethyl-2, 6-octadien-1-yl acetoacetate. Geranyl acetone; 6,10-dimethyl-5,9-undecadien-2-one. Geranyl benzoate. Geranyl butyrate. Geranyl formate. Geranyl hexanoate Geranyl isobutyrate. Geranyl isovalerate. Geranyl phenylacetate. Geranyl propionate. Glucose pentaacetate. Guaiacol; μ-methoxyphenol. Guaiacyl acetate; μ-methoxyphenyl acetate. Guaiacyl phenylacetate. Guaiene; 1,4-dimethyl-7-isopropenyl-Δ9,10-octahydroazulene. Guaiol acetate; 1,4-dimethyl-7-(α-hydroxy-isopropyl)-δ9,10-octahydroazulene acetate. γ-Heptalactone; 4-hydroxyheptanoic acid, γ-lactone. Heptanal; enanthaldehyde. Heptanal dimethyl acetal. Heptanal 1,2-glyceryl acetal. 2,3-Heptanedione; acetyl valeryl. 3-Heptanol. 2-Heptanone; methyl amyl ketone. 3-Heptanone; ethyl butyl ketone. 4-Heptanone; dipropyl ketone. cis-4-Heptenal; cis-4-hepten-1-al. Heptyl acetate. Heptyl alcohol; enanthic alcohol. Heptyl butyrate. Heptyl cinnamate. Heptyl formate. Heptyl isobutyrate. Heptyl octanoate. 1-Hexadecanol; cetyl alcohol. ω-6-Hexadecenlactone; 16-hydroxy-6-hexadecenoic acid, ω-lactone; ambrettolide. γ-Hexalactone; 4-hydroxyhexanoic acid, γ-lactone; tonkalide. Hexanal; caproic aldehyde. 2,3-Hexanedione; acetyl butyryl. Hexanoic acid; caproic acid. 2-Hexenal. 2-Hexen-1-ol. 3-Hexen-1-ol; leaf alcohol. 2-Hexen-1-yl acetate. 3-Hexenyl isovalerate. 3-Hexenyl 2-methylbutyrate. 3-Hexenyl phenylacetate; cis-3-hexenyl phenylacetate. Hexyl acetate. 2-Hexyl-4-acetoxytetrahydrofuran. Hexyl alcohol. Hexyl butyrate. α-Hexylcinnamaldehyde. Hexyl formate. Hexyl hexanoate. 2-Hexylidene cyclopentanone. Hexyl isovalerate. Hexyl 2-methylbutyrate. Hexyl octanoate. Hexyl phenylacetate; n-hexyl phenylacetate. Hexyl propionate. Hydroxycitronellal; 3,7-dimethyl-7-hydroxy-octanal. Hydroxycitronellal diethyl acetal. Hydroxycitronellal dimethyl acetal. Hydroxycitronellol; 3,7-dimethyl-1,7-octanediol. N-(4-Hydroxy-3-methoxybenzyl)-nonanamide; pelargonyl vanillylamide. 5-Hydroxy-4-octanone; butyroin. 4-(p-Hydroxyphenyl)-2-butanone; p-hydroxybenzyl acetone. Indole. α-Ionone; 4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-buten-2-one. β-Ionone; 4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-3-buten-2-one. α-Irone; 4-(2,5,6,6-tetramethyl-2-cyclohexene-1-yl)-3-buten-2-one; 6-methylionone. Isoamyl acetate. Isoamyl acetoacetate. Isoamyl alcohol; isopentyl alcohol; 3-methyl-1-butanol. Isoamyl benzoate. Isoamyl butyrate. Isoamyl cinnamate. Isoamyl formate. Isoamyl 2-furanbutyrate; α-isoamyl furfurylpropionate. Isoamyl 2-furanpropionate; α-isoamyl furfurylacetate. Isoamyl hexanoate. Isoamyl isobutyrate. Isoamyl isovalerate. Isoamyl laurate. Isoamyl-2-methylbutyrate; isopentyl-2-methylbutyrate. Isoamyl nonanoate. Isoamyl octanoate. Isoamyl phenylacetate. Isoamyl propionate. Isoamyl pyruvate. Isoamyl salicylate. Isoborneol. Isobornyl acetate. Isobornyl formate. Isobornyl isovalerate. Isobornyl propionate. Isobutyl acetate. Isobutyl acetoacetate. Isobutyl alcohol. Isobutyl angelate; isobutyl cis-2-methyl-2-butenoate. Isobutyl anthranilate. Isobutyl benzoate. Isobutyl butyrate. Isobutyl cinnamate. Isobutyl formate. Isobutyl 2-furanpropionate. Isobutyl heptanoate. Isobutyl hexanoate. Isobutyl isobutyrate. α-Isobutylphenethyl alcohol; isobutyl benzyl carbinol; 4-methyl-1-phenyl-2-pentanol. Isobutyl phenylacetate. Isobutyl propionate. Isobutyl salicylate. 2-Isobutylthiazole. Isobutyraldehyde. Isobutyric acid. Isoeugenol; 2-methoxy-4-propenylphenol. Isoeugenyl acetate. Isoeugenyl benzyl ether; benzyl isoeugenol. Isoeugenyl ethyl ether; 2-ethoxy-5-propenyl-anisole; ethyl isoeugenol. Isoeugenyl formate. Isoeugenyl methyl ether; 4-propenylveratrole; methyl isoeugenol. Isoeugenyl phenylacetate. Isojasmone; mixture of 2-hexylidenecyclopentanone and 2-hexyl-2-cyclopenten-1-one. α-Isomethylionone; 4-(2,6,6-trimethyl-2-cyclohexen-1-yl)-3-methyl-3-buten-2-one; methyl γ-ionone. Isopropyl acetate. ρ-Isopropylacetophenone. Isopropyl alcohol; isopropanol. Isopropyl benzoate. ρ-Isopropylbenzyl alcohol; cuminic alcohol; ρ-cymen-7-ol. Isopropyl butyrate. Isopropyl cinnamate. Isopropyl formate. Isopropyl hexanoate. Isopropyl isobutyrate. Isopropyl isovalerate. ρ-Isopropylphenylacetaldehyde; ρ-cymen-7-carboxaldehyde. Isopropyl phenylacetate. 3-(ρ-Isopropylphenyl)-propionaldehyde; ρ-isopropylhydrocinnamaldehyde; cuminyl acetaldehyde. Isopropyl propionate. Isopulegol; p-menth-8-en-3-ol. Isopulegone; p-menth-8-en-3-one. Isopulegyl acetate. Isoquinoline. Isovaleric acid. cis-Jasmone; 3-methyl-2-(2-pentenyl)-2-cyclopenten-1-one. Lauric aldehyde; dodecanal. Lauryl acetate. Lauryl alcohol; 1-dodecanol. Lepidine; 4-methylquinoline. Levulinic acid. Linalool oxide; cis- and trans-2-vinyl-2-methyl-5-(1′-hydroxy-1′-methylethyl) tetrahydrofuran. Linalyl anthranilate; 3,7-dimethyl-1,6-octadien-3-yl anthranilate. Linalyl benzoate. Linalyl butyrate. Linalyl cinnamate. Linalyl formate. Linalyl hexanoate. Linalyl isobutyrate. Linalyl isovalerate. Linalyl octanoate. Linalyl propionate. Maltol; 3-hydroxy-2-methyl-4H-pyran-4-one. Menthadienol; p-mentha-1,8(10)-dien-9-ol. p-Mentha-1,8-dien-7-ol; perillyl alcohol. Menthadienyl acetate; p-mentha-1,8(10)-dien-9-yl acetate. p-Menth-3-en-1-ol. 1-p-Menthen--9-yl acetate; p-menth-1-en-9-yl acetate. Menthol; 2-isopropyl-5-methylcyclohexanol. Menthone; p-menthan-3-one. Menthyl acetate; p-menth-3-yl acetate. Menthyl isovalerate; p-menth-3-yl isovalerate. o-Methoxybenzaldehyde. p-Methoxybenzaldehyde; p-anisaldehyde. o-Methoxycinnamaldehyde. 2-Methoxy-4-methylphenol; 4-methylguaiacol; 2-methoxy-p-cresol. 4-(p-Methoxyphenyl)-2-butanone; anisyl acetone. 1-(4-Methoxyphenyl)-4-methyl-1-penten-3-one; methoxystyryl isopropyl ketone. 1-(p-Methoxyphenyl)-1-penten-3-one; α-methylanisylidene acetone; ethone. 1-(p-Methoxyphenyl)-2-propanone; anisylmethyl ketone; anisic ketone. 2-Methoxy-4-vinylphenol; p-vinylguaiacol. Methyl acetate. 4′-Methylacetophenone; p-methylacetophenone; methyl p-tolyl ketone. 2-Methylallyl butyrate; 2-methyl-2-propenl-yl butyrate. Methyl anisate. o-Methylanisole; o-cresyl methyl ether. p-Methylanisole; p-cresyl methyl ether; p-methoxytoluene. Methyl benzoate. Methylbenzyl acetate, mixed o-,m-,p-. α-Methylbenzyl acetate; styralyl acetate. α-Methylbenzyl alcohol; styralyl alcohol. α-Methylbenzyl butyrate; styralyl butyrate. α-Methylbenzyl isobutyrate; styralyl isobutyrate. α-Methylbenzyl formate; styralyl formate. α-Methylbenzyl propionate; styralyl propionate. 2-Methyl-3-buten-2-ol. 2-Methylbutyl isovalerate. Methyl p-tert-butylphenylacetate. 2-Methylbutyraldehyde; methyl ethyl acetaldehyde. 3-Methylbutyraldehyde; isovaleraldehyde. Methyl butyrate. 2-Methylbutyric acid. α-Methylcinnamaldehyde. p-Methylcinnamaldehyde. Methyl cinnamate. 2-Methyl-1,3-cyclohexadiene. Methylcyclopentenolone; 3-methylcyclopentane-1,2-dione. Methyl disulfide; dimethyl disulfide. Methyl ester of rosin, partially hydrogenated (as defined in § 172.615); methyl dihydroabietate. Methyl heptanoate. 2-Methylheptanoic acid. 6-Methyl-3,5-heptadien-2-one. Methyl-5-hepten-2-ol. 6-Methyl-5-hepten-2-one. Methyl hexanoate. Methyl 2-hexanoate. Methyl p-hydroxybenzoate; methylparaben. Methyl α-ionone; 5-(2,6,6-trimethyl-2-cyclohexen-1-yl)-4-penten-3-one. Methyl β-ionone; 5-(2,6,6-trimethyl-1-cyclohexen-1-yl)-4-penten-3-one. Methyl Δ-ionone; 5-(2,6,6-trimethyl-3-cyclohexen-1-yl-)-4-penten-3-one. Methyl isobutyrate. 2-Methyl-3-(p-isopropylphenyl)-propionalde-hyde; α-methyl-p-isopropylhydro- cinnamal- dehyde; cyclamen aldehyde. Methyl isovalerate. Methyl laurate. Methyl mercaptan; methanethiol. Methyl o-methoxybenzoate. Methyl N-methylanthranilate; dimethyl anthranilate. Methyl 2-methylbutyrate. Methyl-3-methylthiopropionate. Methyl 4-methylvalerate. Methyl myristate. Methyl β-naphthyl ketone; 2′-acetonaphthone. Methyl nonanoate. Methyl 2-nonenoate. Methyl 2-nonynoate; methyloctyne carbonate. 2-Methyloctanal; methyl hexyl acetaldehyde. Methyl octanoate. Methyl 2-octynoate; methyl heptine carbonate. 4-Methyl-2,3-pentanedione; acetyl isobutyryl. 4-Methyl-2-pentanone; methyl isobutyl ketone. β-Methylphenethyl alcohol; hydratropyl alcohol. Methyl phenylacetate. 3-Methyl-4-phenyl-3-butene-2-one. 2-Methyl-4-phenyl-2-butyl acetate; dimethylphenylethyl carbinyl acetate. 2-Methyl-4-phenyl-2-butyl isobutyrate; dimethylphenyl ethylcarbinyl isobutyrate. 3-Methyl-2-phenylbutyraldehyde; α-isopropyl phenylacetaldehyde. Methyl 4-phenylbutyrate. 4-Methyl-1-phenyl-2-pentanone; benzyl isobutyl ketone. Methyl 3-phenylpropionate; methyl hydrocinnamate. Methyl propionate. 3-Methyl-5-propyl-2-cyclohexen-1-one. Methyl sulfide. 3-Methylthiopropionaldehyde; methional. 2-Methyl-3-tolylpropionaldehyde, mixed o-, m-, p-. 2-Methylundecanal; methyl nonyl acetaldehyde. Methyl 9-undecenoate. Methyl 2-undecynoate; methyl decyne carbonate. Methyl valerate. 2-Methylvaleric acid. Myristaldehyde; tetradecanal. d-Neomenthol; 2-isopropyl-5-methylcyclohexanol. Nerol; cis-3,7-dimethyl-2,6-octadien-1-ol. Nerolidol; 3,7,11-trimethyl-1,6,10-dodecatrien-3-ol. Neryl acetate. Neryl butyrate. Neryl formate. Neryl isobutyrate. Neryl isovalerate. Neryl propionate. 2,6-Nonadien-1-ol. γ-Nonalactone; 4-hydroxynonanoic acid, γ-lactone; aldehyde C-18. Nonanal; pelargonic aldehyde. 1,3-Nonanediol acetate, mixed esters. Nonanoic acid; pelargonic acid. 2-Nonanone; methylheptyl ketone. 3-Nonanon-1-yl acetate; 1-hydroxy-3-nonanone acetate. Nonyl acetate. Nonyl alcohol; 1-nonanol. Nonyl octanoate. Nonyl isovalerate. Nootkatone; 5,6-dimethyl-8-isopropenyl-bicyclo[4,4,0]-dec-1-en-3-one. Ocimene; trans-β-ocimene; 3,7-dimethyl-1,3,6-octatriene. γ-Octalactone; 4-hydroxyoctanoic acid, γ-lactone. Octanal; caprylaldehyde. Octanal dimethyl acetal. 1-Octanol; octyl alcohol. 2-Octanol. 3-Octanol. 2-Octanone; methyl hexyl ketone. 3-Octanone; ethyl amyl ketone. 3-Octanon-1-ol. 1-Octen-3-ol; amyl vinyl carbinol. 1-Octen-3-yl acetate. Octyl acetate. 3-Octyl acetate. Octyl butyrate. Octyl formate. Octyl heptanoate. Octyl isobutyrate. Octyl isovalerate. Octyl octanoate. Octyl phenylacetate. Octyl propionate. ω-Pentadecalactone; 15-hydroxypentadeca-noic acid, ω-lactone; pentadecanolide; angelica lactone. 2,3-Pentanedione; acetyl propionyl. 2-Pentanone; methyl propyl ketone. 4-Pentenoic acid. 1-Penten-3-ol. Perillaldehyde; 4-isopropenyl-1-cyclohexene-1-carboxaldehyde;p-mentha-1,8-dien-7-al. Perillyl acetate; p-mentha-1,8-dien-7-yl acetate. α-Phellandrene; ρ-mentha-1,5-diene. Phenethyl acetate. Phenethyl alcohol; β-phenylethyl alcohol. Phenethyl anthranilate. Phenethyl benzoate. Phenethyl butyrate. Phenethyl cinnamate. Phenethyl formate. Phenethyl isobutyrate. Phenethyl isovalerate. Phenethyl 2-methylbutyrate. Phenethyl phenylacetate. Phenethyl propionate. Phenethyl salicylate. Phenethyl senecioate; phenethyl 3,3-dimethylacrylate. Phenethyl tiglate. Phenoxyacetic acid. 2-Phenoxyethyl isobutyrate. Phenylacetaldehyde; α-toluic aldehyde. Phenylacetaldehyde 2,3-butylene glycol acetal. Phenylacetaldehyde dimethyl acetal. Phenylacetaldehyde glyceryl acetal. Phenylacetic acid; α-toluic acid. 4-Phenyl-2-butanol; phenylethyl methyl carbinol. 4-Phenyl-3-buten-2-ol; methyl styryl carbinol. 4-Phenyl-3-buten-2-one. 4-Phenyl-2-butyl acetate; phenylethyl methyl carbinyl acetate. 1-Phenyl-3-methyl-3-pentanol; phenylethyl methyl ethyl carbinol. 1-Phenyl-1-propanol; phenylethyl carbinol. 3-Phenyl-1-propanol; hydrocinnamyl alcohol. 2-Phenylpropionaldehyde; hydratropalde-hyde. 3-Phenylpropionaldehyde; hydrocinnamaldehyde. 2-Phenylpropionalde-hyde dimethyl acetal; hydratropic aldehyde dimethyl acetal. 3-Phenylpropionic acid; hydrocinnamic acid. 3-Phenylpropyl acetate. 2-Phenylpropyl butyrate. 3-Phenylpropyl cinnamate. 3-Phenylpropyl formate. 3-Phenylpropyl hexanoate. 2-Phenylpropyl isobutyrate. 3-Phenylpropyl isobutyrate. 3-Phenylpropyl isovalerate. 3-Phenylpropyl propionate. 2-(3-Phenylpropyl)-tetrahydrofuran. α-Pinene; 2-pinene. β-Pinene; 2(10)-pinene. Pine tar oil. Pinocarveol; 2(10)-pinen-3-ol. Piperidine. Piperine. d-Piperitone; p-menth-1-en-3-one. Piperitenone; p-mentha-1,4(8)-dien-3-one. Piperitenone oxide; 1,2-epoxy-p-menth-4-(8)-en-3-one. Piperonyl acetate; heliotropyl acetate. Piperonyl isobutyrate. Polylimonene. Polysorbate 20; polyoxyethylene (20) sorbitan monolaurate. Polysorbate 60; polyoxyethylene (20) sorbitan monostereate. Polysorbate 80; polyoxyethylene (20) sorbitan monooleate. Potassium acetate. Propenylguaethol; 6-ethoxy-m-anol. Propionaldehyde. Propyl acetate. Propyl alcohol; 1-propanol. p-Propyl anisole; dihydroanethole. Propyl benzoate. Propyl butyrate. Propyl cinnamate. Propyl disulfide. Propyl formate. Propyl 2-furanacrylate. Propyl heptanoate. Propyl hexanoate. Propyl p-hydroxybenzoate; propylparaben. 3-Propylidenephthalide. Propyl isobutyrate. Propyl isovalerate. Propyl mercaptan. α-Propylphenethyl alcohol. Propyl phenylacetate. Propyl propionate. Pyroligneous acid extract. Pyruvaldehyde. Pyruvic acid. Rhodinol; 3,7-dimethyl-7-octen-1-ol; l-citronellol. Rhodinyl acetate. Rhodinyl butyrate. Rhodinyl formate. Rhodinyl isobutyrate. Rhodinyl isovalerate. Rhodinyl phenylacetate. Rhodinyl propionate. Rum ether; ethyl oxyhydrate. Salicylaldehyde. Santalol, α and β. Santalyl acetate. Santalyl phenylacetate. Skatole. Sorbitan monostearate. Sucrose octaacetate. α-Terpinene. γ-Terpinene. α-Terpineol; p-menth-1-en-8-ol. β-Terpineol. Terpinolene; p-menth-1,4(8)-diene. Terpinyl acetate. Terpinyl anthranilate. Terpinyl butyrate. Terpinyl cinnamate. Terpinyl formate. Terpinyl isobutyrate. Terpinyl isovalerate. Terpinyl propionate. Tetrahydrofurfuryl acetate. Tetrahydrofurfuryl alcohol. Tetrahydrofurfuryl butyrate. Tetrahydrofurfuryl propionate. Tetrahydro-pseudo-ionone; 6,10-dimethyl-9-undecen-2-one. Tetrahydrolinalool; 3,7-dimethyloctan-3-ol. Tetramethyl ethylcyclohexenone; mixture of 5-ethyl-2,3,4,5-tetramethyl-2-cyclohexen-1-one and 5-ethyl-3,4,5,6-tetramethyl-2-cyclohexen-1-one. 2-Thienyl mercaptan; 2-thienylthiol. Thymol. Tolualdehyde glyceryl acetal, mixed o, m, p. Tolualdehydes, mixed o, m, p. p-Tolylacetaldehyde. o-Tolyl acetate; o-cresyl acetate. p-Tolyl acetate; p-cresyl acetate. 4-(p-Tolyl)-2-butanone; p-methylbenzylacetone. p-Tolyl isobutyrate. p-Tolyl laurate. p-Tolyl phenylacetate. 2-(p-Tolyl)-propionaldehyde; p-methylhydratropic aldehyde. Tributyl acetylcitrate. 2-Tridecenal. 2,3-Undecadione; acetyl nonyryl. γ-Undecalactone; 4-hydroxyundecanoic acid γ-lactone; peach aldehyde; aldehyde C-14. Undecenal. 2-Undecanone; methyl nonyl ketone. 9-Undecenal; undecenoic aldehyde. 10-Undecenal. Undecen-1-ol; undecylenic alcohol. 10-Undecen-1-yl acetate. Undecyl alcohol. Valeraldehyde; pentanal. Valeric acid; pentanoic acid. Vanillin acetate; acetyl vanillin. Veratraldehyde. Verbenol; 2-pinen-4-ol. Zingerone; 4-(4-hydroxy-3-methoxyphenyl)-2-butanone.

(c) Δ-Decalactone and Δ-dodecalactone when used separately or in combination in oleomargarine are used at levels not to exceed 10 parts per million and 20 parts per million, respectively, in accordance with § 166.110 of this chapter.

(d) BHA (butylated hydroxyanisole) may be used as an antioxidant in flavoring substances whereby the additive does not exceed 0.5 percent of the essential (volatile) oil content of the flavoring substance.

[42 FR 14491, Mar. 15, 1977, as amended at 42 FR 23148, May 6, 1977; 43 FR 19843, May 9, 1978; 45 FR 22915, Apr. 4, 1980; 47 FR 27810, June 25, 1982; 48 FR 10812, Mar. 15, 1983; 48 FR 51907, Nov. 15, 1983; 49 FR 5747, Feb. 15, 1984; 50 FR 42932, Oct. 23, 1985; 54 FR 7402, Feb. 21, 1989; 61 FR 14245, Apr. 1, 1996; 69 FR 24511, May 4, 2004; 83 FR 50490, 50503, Oct. 9, 2018]

§ 172.520 - Cocoa with dioctyl sodium sulfosuccinate for manufacturing.

The food additive “cocoa with dioctyl sodium sulfosuccinate for manufacturing,” conforming to § 163.117 of this chapter and § 172.810, is used or intended for use as a flavoring substance in dry beverage mixes whereby the amount of dioctyl sodium sulfosuccinate does not exceed 75 parts per million of the finished beverage. The labeling of the dry beverage mix shall bear adequate directions to assure use in compliance with this section.

§ 172.530 - Disodium guanylate.

Disodium guanylate may be safely used as a flavor enhancer in foods, at a level not in excess of that reasonably required to produce the intended effect.

§ 172.535 - Disodium inosinate.

The food additive disodium inosinate may be safely used in food in accordance with the following prescribed conditions:

(a) The food additive is the disodium salt of inosinic acid, manufactured and purified so as to contain no more than 150 parts per million of soluble barium in the compound disodium inosinate with seven and one-half molecules of water of crystallization.

(b) The food additive is used as a flavoring adjuvant in food.

§ 172.540 - DL-Alanine.

DL-Alanine (a racemic mixture of D- and L-alanine; CAS Reg. No. 302-72-7) may be safely used as a flavor enhancer for sweeteners in pickling mixtures at a level not to exceed 1 percent of the pickling spice that is added to the pickling brine.

[56 FR 6968, Feb. 21, 1991]

§ 172.560 - Modified hop extract.

The food additive modified hop extract may be safely used in beer in accordance with the following prescribed conditions:

(a) The food additive is used or intended for use as a flavoring agent in the brewing of beer.

(b) The food additive is manufactured by one of the following processes:

(1) The additive is manufactured from a hexane extract of hops by simultaneous isomerization and selective reduction in an alkaline aqueous medium with sodium borohydride, whereby the additive meets the following specifications:

(i) A solution of the food additive solids is made up in approximately 0.012 n alkaline methyl alcohol (6 milliliters of 1 n sodium hydroxide diluted to 500 milliliters with methyl alcohol) to show an absorbance at 253 millimicrons of 0.6 to 0.9 per centimeter. (This absorbance is obtained by approximately 0.03 milligram solids permilliliter.) The ultraviolet absorption spectrum of this solution exhibits the following characteristics: An absorption peak at 253 millimicrons; no absorption peak at 325 to 330 millimicrons; the absorbance at 268 millimicrons does not exceed the absorbance at 272 millimicrons.

(ii) The boron content of the food additive does not exceed 310 parts per million (0.0310 percent), calculated as boron.

(2) The additive is manufactured from hops by a sequence of extractions and fractionations, using benzene, light petroleum spirits, and methyl alcohol as solvents, followed by isomerization by potassium carbonate treatment. Residues of solvents in the modified hop extract shall not exceed 1.0 part per million of benzene, 1.0 part per million of light petroleum spirits, and 250 parts per million of methyl alcohol. The light petroleum spirits and benzene solvents shall comply with the specifications in § 172.250 except that the boiling point range for light petroleum spirits is 150 °F-300 °F.

(3) The additive is manufactured from hops by a sequence of extractions and fractionations, using methylene chloride, hexane, and methyl alcohol as solvents, followed by isomerization by sodium hydroxide treatment. Residues of the solvents in the modified hop extract shall not exceed 5 parts per million of methylene chloride, 25 parts per million of hexane, and 100 parts per million of methyl alcohol.

(4) The additive is manufactured from hops by a sequence of extractions and fractionations, using benzene, light petroleum spirits, methyl alcohol, n-butyl alcohol, and ethyl acetate as solvents, followed by isomerization by potassium carbonate treatment. Residues of solvents in the modified hop extract shall not exceed 1.0 part per million of benzene, 1.0 part per million of light petroleum spirits, 50 parts per million of methyl alcohol, 50 parts per million of n-butyl alcohol, and 1 part per million of ethyl acetate. The light petroleum spirits and benzene solvents shall comply with the specifications in § 172.250 except that the boiling point range for light petroleum spirits is 150 °F to 300 °F.

(5) The additive is manufactured from hops by an initial extraction and fractionation using one or more of the following solvents: Ethylene dichloride, hexane, isopropyl alcohol, methyl alcohol, methylene chloride, trichloroethylene, and water; followed by isomerization by calcium chloride or magnesium chloride treatment in ethylene dichloride, methylene chloride, or trichloroethylene and a further sequence of extractions and fractionations using one or more of the solvents set forth in this paragraph. Residues of the solvents in the modified hop extract shall not exceed 125 parts per million of hexane; 150 parts per million of ethylene dichloride, methylene chloride, or trichloroethylene; or 250 parts per million of isopropyl alcohol or methyl alcohol.

(6) The additive is manufactured from hops by an initial extraction and fractionation using one or more of the solvents listed in paragraph (b)(5) of this section followed by: Hydrogenation using palladium as a catalyst in methyl alcohol, ethyl alcohol, or isopropyl alcohol acidified with hydrochloric or sulfuric acid; oxidation with peracetic acid; isomerization by calcium chloride or magnesium chloride treatment in ethylene dichloride, methylene chloride, or trichloroethylene (alternatively, the hydrogenation and isomerization steps may be performed in reverse order); and a further sequence of extractions and fractionations using one or more of the solvents listed in paragraph (b)(5) of this section. The additive shall meet the residue limitations as prescribed in paragraph (b)(5) of this section.

(7) The additive is manufactured from hops as set forth in paragraph (b)(6) of this section followed by reduction with sodium borohydride in aqueous alkaline methyl alcohol, and a sequence of extractions and fractionations using one or more of the solvents listed in paragraph (b)(5) of this section. The additive shall meet the residue limitations as prescribed in paragraph (b)(5) of this section, and a boron content level not in excess of 300 parts per million (0.0300 percent), calculated as boron.

(8) The additive is manufactured from hops as a nonisomerizable nonvolatile hop resin by an initial extraction and fractionation using one or more of the solvents listed in paragraph (b)(5) of this section followed by a sequence of aqueous extractions and removal of nonaqueous solvents to less than 0.5 percent. The additive is added to the wort before or during cooking in the manufacture of beer.

§ 172.575 - Quinine.

Quinine, as the hydrochloride salt or sulfate salt, may be safely used in food in accordance with the following conditions:

Uses	Limitations	In carbonated beverages as a flavor	Not to exceed 83 parts per million, as quinine. Label shall bear a prominent declaration of the presence of quinine either by the use of the word “quinine” in the name of the article or through a separate declaration.

§ 172.580 - Safrole-free extract of sassafras.

The food additive safrole-free extract of sassafras may be safely used in accordance with the following prescribed conditions:

(a) The additive is the aqueous extract obtained from the root bark of the plant Sassafras albidum (Nuttall) Nees (Fam. Lauraceae).

(b) It is obtained by extracting the bark with dilute alcohol, first concentrating the alcoholic solution by vacuum distillation, then diluting the concentrate with water and discarding the oily fraction.

(d) It is used as a flavoring in food.

§ 172.585 - Sugar beet extract flavor base.

Sugar beet extract flavor base may be safely used in food in accordance with the provisions of this section.

(a) Sugar beet extract flavor base is the concentrated residue of soluble sugar beet extractives from which sugar and glutamic acid have been recovered, and which has been subjected to ion exchange to minimize the concentration of naturally occurring trace minerals.

(b) It is used as a flavor in food.

§ 172.590 - Yeast-malt sprout extract.

Yeast-malt sprout extract, as described in this section, may be safely used in food in accordance with the following prescribed conditions:

(a) The additive is produced by partial hydrolysis of yeast extract (derived from Saccharomyces cereviseae, Saccharomyces fragilis, or Candida utilis) using the sprout portion of malt barley as the source of enzymes. The additive contains a maximum of 6 percent 5′ nucleotides by weight.

(b) The additive may be used as a flavor enhancer in food at a level not in excess of that reasonably required to produce the intended effect.